Densin and Ca /Calmodulin-Dependent Protein Kinase II
نویسندگان
چکیده
Meagan A. Jenkins,1* Carl J. Christel,2* Yuxia Jiao,4 Sunday Abiria,4 Kristin Y. Kim,2 Yuriy M. Usachev,3 Gerald J. Obermair,5 Roger J. Colbran,4 and Amy Lee2 1Department of Pharmacology, Emory University, Atlanta, Georgia 30322, Departments of 2Molecular Physiology and Biophysics and 3Pharmacology, University of Iowa, Iowa City, Iowa 52242, 4Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, and 5Department of Physiology and Medical Physics, Innsbruck Medical University, A-6020 Innsbruck, Austria
منابع مشابه
Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.
In a continuing search for proteins that target calcium/calmodulin-dependent protein kinase II (CaMKII) to postsynaptic density (PSD) substrates important in synaptic plasticity, we showed that the PSD protein densin-180 binds CaMKII. Four putative splice variants (A-D) of the cytosolic tail of densin-180 are shown to be differentially expressed during brain development. Densin-180 splicing aff...
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Densin-180 is a transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Here we report the identification of the a-subunit of Ca/ calmodulin-dependent protein kinase II (CaMKII) and a-actinin-4 as potential binding partners for the densin-180 intracellular segment. We demonstrate by yeast two-hy...
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The aim of this study was to investigate (a) whether Ca /calmodulin-dependent protein kinase II (CaM kinase II) participates in the regulation of plasma membrane Ca -ATPase and (b) its possible cross-talk with other kinase-mediated modulatory pathways of the pump. Using isolated innervated membranes of the electrocytes from Electrophorus electricus L., we found that stimulation of endogenous pr...
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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Na channel regulation by Ca/calmodu...
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