A small molecule that binds and inhibits the ETV 1 transcription factor
نویسندگان
چکیده
Affiliations: 1 Dana Farber Cancer Institute, Boston, MA, USA 2 Broad Institute, Cambridge, MA, USA 3 Novartis Institute for Biomedical Research, Cambridge, MA, USA 4 Department of Biological Engineering, MIT, Cambridge, MA, USA 5 Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA # Current address: Blueprint medicines, Cambridge, MA, USA *Corresponding author: Levi A Garraway Dana-Farber Cancer Institute 450 Brookline Ave, D1542 Boston, MA 02115-6048 617.632.6689 tel, 617.582.7880 fax [email protected] www.dana-farber.org
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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.
Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 wo...
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