Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
نویسندگان
چکیده
After publication, the authors realized that an antibody and siRNAs used in the paper were incorrect. Specifically, the antibody reported as Cdh1 in Fig. 5 E was instead an antibody against CDH1 (Cadherin). In addition, the three siRNAs in Fig. 5 E reported as siCdh1#1, siCdh1#2, and siCdh1#3 were also inadvertently synthesized against CDH1 (Cadherin). Upon discovering the error, the authors generated three correct siRNAs against Cdh1, obtained an antibody against Cdh1, and repeated the experiment in Fig. 5 E. The incorrect resources were not used in any other part of the paper and the conclusions are not affected by this correction.
منابع مشابه
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
Glycolytic enzymes are known to play pivotal roles in cancer cell survival, yet their molecular mechanisms remain poorly understood. Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells. Herein, we report that PGAM1 is required for homologous recombination (HR) repair of DNA double-str...
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295 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 2 295–297 https://doi.org/10.1083/jcb.201701026 Deregulated metabolism is a hallmark of cancer. Most normal differentiated cells only display low glycolysis rates, of which the resulting pyruvate is used to produce ATP through aerobic phosphorylation. In contrast, tumor cells have highly increased rates of glycolysis, after ...
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