Author's response to reviews Administration of Zoledronic Acid Enhances the Effects of Docetaxel on Growth of Prostate Cancer in Title: the Bone Environment Authors:

We thank Reviewer #1 for his constructive comments. * We agree that BV/TV often correlates with measurements of BMD. However, bone volume and bone mineral density represent different aspects of the bone, and do not necessarily have to correlate. Bone mineral density evaluates the mineral content of the bone, while bone volume is the space occupied by the bone, regardless of the mineral content. A small volume of bone can have a large mineral density. The discordance of these two parameters in our study might be due to effects of the treatment on mineral deposition, but also to the methodology used. BV was measured in the whole longitudinal section of the tibiae, while BMD was measured in the region adjacent to the growth plate. We have added a comment on this issue to the manuscript.