Urinary Enzymes Excretion after Acute Administration of Paracetamol in Patients with Kidney Disease

The effect of paracetamol, commonly used as analgesic drug, upon excretion of some enzymes, markers of kidney damage, was investigated. Patients with Balkan endemic nephropathy and glomerulonephritis, having kidney vulnerable to toxic drugs, were enrolled in the study. Timed urine specimens were collected: before drug administration, and in 3h periods for 24 h after an oral dose of 2 g of paracetamol. Excretion of APN activity related to mmol creatinine before paracetamol treatment was significantly higher in patients with glomerulonephritis than in healthy persons from the city or village, and from BEN patients. Urinary excretion of DPP IV and GGT was significantly increased in patients with glomerulonephritis, BEN, and in clinically healthy inhabitants of the endemic villages compared to healthy adults from the city. After paracetamol administration urinary excretion of APN, DPP IV and GGT did not change significantly in any group studied. This study has shown that urinary excretion of APN, DPP IV and GGT, as markers of kidney brush border damage, did not change after 2 g of paracetamol taken orally.