Guidelines for the diagnosis and management of adult myelodysplastic syndromes.

Acute myeloblastic leukaemias and myelodysplastic syndromes in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

The yearly incidence of the acute myeloblastic leukaemias (AMLs) in European adults is 5–8 cases per 100 000 individuals, and in myelodysplastic syndromes (MDSs) 4–5 new cases/100 000 are expected yearly. In individuals >60 years incidences of both AMLs and MDSs increase significantly, reaching 40–60 new cases of MDS per 100 000/year. Yearly mortality figures are 4–6 cases per 100 000 in AMLs a...

Guidelines for standardized diagnostic and prognostic procedures in adult myelodysplastic syndromes

Range Determination of Antigen Expression in Myeloid, Erythroid and Lymphoid Cell Lineages among Patients with Myelodysplastic Syndrome

Background: Myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. Understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. Patients and Methods: We compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome ...

Hamartomatous Polyposis Syndromes: Management and Surveillance Strategies

Introduction: Hamartomatous Polyposis Syndromes (HPS) are a rare group of dominant autosomal inheritance, which is characterized by the development of hamartomatous polyps in the gastrointestinal tract.  This syndrome included Juvenile Polyposis syndrome (JPS), Peutz-Jeghers syndrome (PJS), and PTEN Hamartoma Tumour Syndrome (PHTS). PTEN Hamartoma Tumour Syndrome (PHTS) itself includes Cowden ...

Diagnosis of Myeloid Sarcoma of Female Breast by Routine Microscopic Findings Using Immunohistochemical Method, Bone Marrow Aspiration and Flow Cytometry

Myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (AML). The tumor mass may precede or occur concurrently with AML, CML, myeloproliferative disorders, and/or myelodysplastic syndromes. Histologically, it looks like a large cell lymphoma and can be misdiagnosed. A case refe...

Hematopathological concepts and controversies in the diagnosis and classification of myelodysplastic syndromes.

Although the diagnosis and classification of most cases of the myelodysplastic syndromes (MDS) is usually accomplished without difficulty, a minority of cases may pose diagnostic problems. In many cases the diagnostic dilemma can be solved by adhering to basic guidelines recommended for evaluation of patients suspected of having MDS, and in particular to the quality of the blood and bone marrow...