Urinary Tumor Markers for Bladder Cancer
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چکیده
Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals: With signs and symptoms of bladder cancer or a history of bladder cancer Interventions of interest are: Urinary tumor marker tests Comparators of interest are: Cytology Cystoscopy Biopsy Relevant outcomes include: Overall survival Disease-specific survival Test accuracy Test validity Resource utilization Individuals: With no signs or symptoms or history of bladder cancer Interventions of interest are: Urinary tumor marker tests Comparators of interest are: No bladder cancer screening Relevant outcomes include: Overall survival Disease-specific survival Test accuracy Test validity
منابع مشابه
E-Cadherin in Relation with the Proliferating Cell Nuclear Antigen of the Bilharzia Associ-ated and Non-Associated Urinary Bladder Carcinoma
Background: E-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. Loss of the adhesive function of E-cadherin seems to promote invasive and metastatic properties of neoplastic cells. Objectives: The present study is a retrospective study aiming to evaluate the loss of E-cadher...
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Currently, there is no perfect test for the detection of bladder cancer. Even the gold standard cystoscopy is increasingly being demonstrated to miss both Tis and papillary bladder cancer. The oldest urine-based biomarker, cytology, has high specificity but has low sensitivity and significant variability in performance. Stage and grade of transitional cell carcinoma are currently the most usefu...
متن کاملWhat are the currently available and in development molecular markers for bladder cancer? Will they prove to be useful in the future?
Urothelial carcinoma is the 9(th) most common cancer worldwide. Most urothelial tumors are non-muscle invasive on presentation. However, two-thirds of non-invasive bladder cancers will eventually recur with a 25% risk of progression to muscle-invasive bladder cancer. Tumor stage, histological grade and pathological invasion of blood vessels and lymphatic tissue are the main indicators for uroth...
متن کاملEvaluation of Sensitivity and Specificity of Urine Survivin As A New Molecular Marker in Diagnosis of Bladder Tumors
Bladder cancer is one of the most common forms of cancers in the world. The current gold standards for itsdiagnosis are cystoscopy and urine cytology. Cystoscopy, a naked eye assessment of the bladder, is invasive, uncomfortable and costly with a great deal of personal variability in its results; while urine cytology has high specificity but low sensitivity, particularly for low-grade les...
متن کاملResearch progress in potential urinary markers for the early detection, diagnosis and follow-up of human bladder cancer.
OBJECTIVE To summarize and evaluate various urinary markers for early detection, diagnosis and follow-up of human bladder cancer. METHODS A MEDLINE and PUBMED search of the latest literature on urinary markers for bladder cancer was performed. We reviewed these published reports and made a critical analysis. RESULTS Most urinary markers tend to be less specific than cytology, yielding more ...
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