Treatment by Imipramine of Deafness and Depression

aminoacid sequences in common which are thought to bind hormones to specific sequences of DNA and modify the gene transcription (Beato, 1989). The complex formed by the binding of a steroid with a receptor is translocated into the cell nucleus where it binds to DNA and influences the expression of genes So the activation in depression of the HPA axis involves various steps in producing excess Cortisol and then inducing genomic change. The blockade at each one of them is being targeted to antagonise the effects of stressful life events in producing depression or in the treatment of depression. The therapeutic potential of antiglucocorticoid drugs especially type II receptor antagonists and steroid synthesis inhibitors have been explored with encouraging results in patients with mood disorders (Mitchell & O'Keanne, 1998).