Antibiotic resistance pattern of group-a beta-hemolytic streptococci isolated from north Indian children.
نویسندگان
چکیده
BACKGROUND The current resistance pattern of GABHS (group-A beta-hemolytic streptococci) in India has not been discussed. AIM To fill the above-mentioned void, we planned this study to determine the prevalence and degree of antibacterial resistance in GABHS isolates. SETTINGS AND DESIGN Children with acute pharyngo-tonsillitis who had not received antibiotic in the preceding week, attending the pediatric OPD, were prospectively enrolled over a period of 1 year. Throat swabs were collected from each child and transported to microbiology laboratory, as early as possible. MATERIALS AND METHODS A throat swab culture for GABHS was done. All GABHS were subjected to antibiotic susceptibility and minimum inhibitory concentration (MIC) test according to Clinical Laboratory Standard Institute (CLSI) guidelines. RESULTS In the present study, 12.6% (55/435) of the children with acute pharyngo-tonsillitis had throat swab culture positive for GABHS. The prevalence of macrolide resistance was 10.2%. The MIC50 for macrolide-resistant strain was 0.5 microg/mL (range, 0.125-8 microg/mL), and MIC90 was 8 microg/mL (range, 0.125-8 microg/mL). Tetracycline and co-trimoxazole resistances were 24.5% and 12.2% respectively. The values of MIC50 for tetracycline- and co-trimoxazole-resistant strains were 4 microg/mL (range, 0.125-32 microg/mL) and 2 microg/mL (range, 0.25-8 microg/mL) respectively. All isolates were sensitive to penicillin G and chloramphenicol on disc diffusion test. However, their MIC50 was 0.032 microg/mL (range, 0.012-0.125 microg/mL) and 2 microg/mL (range, 0.25-4 microg/mL) respectively. CONCLUSION High prevalence of antimicrobial resistance found among GABHS needs a longitudinal surveillance of isolates from different centers in India.
منابع مشابه
مقاومت آنتیبیوتیکی استرپتوکوک بتا همولیتیک گروه A در کودکان حامل بدون علامت در شهرستان رفسنجان در سال 1388
Received: 20/08/2011 Sent for Revision: 21/11/2011 Received Revised Manuscript: 14/07/2012 Accepted: 04/08/2012 background and Objective: Group A Beta hemolytic streptococci (GABHS) is the most common bacterial cases of acute pharyngitis in school children. Diagnosis of the etiological agent and appropriate anibiotic therapy is important. The aim of this study was to determine the antibio...
متن کاملGroup-A beta-hemolytic streptococci resistance pattern in north Indian pediatric population.
Sir, The interesting article by Jain et al. describes the resistance pattern of GABHS (group-A beta-hemolytic streptococci) in northern India.[1] The article may be of immense interest to all clinicians. The authors mention in the abstract section that the current resistance pattern of GABHS has not been discussed in India, which is incorrect. A thorough search of literature reveals that Lloyd ...
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ورودعنوان ژورنال:
- Indian journal of medical sciences
دوره 62 10 شماره
صفحات -
تاریخ انتشار 2008