Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes.
نویسندگان
چکیده
In T lymphocytes, a store-operated calcium ion (Ca2+) entry mechanism termed the calcium release-activated Ca2+ channel (CRAC channel) underlies the sustained or oscillatory intracellular calcium concentration signal required for interleukin-2 gene expression and cell proliferation. The use of sodium ions as a current carrier enabled single-channel recordings of CRAC channels during activation, inactivation, and blockade of current in the presence of divalent cations. A large conductance of 36 to 40 picosiemens indicates that 100 to 400 CRAC channels are present in T lymphocytes.
منابع مشابه
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ورودعنوان ژورنال:
- Science
دوره 283 5403 شماره
صفحات -
تاریخ انتشار 1999