Comparison of the diagnostic accuracy of BNP and NT-proBNP in acute and chronic heart failure.
نویسنده
چکیده
when the infant was 18 months old, and again this sample showed evidence of significant hemolysis, with decreased hemoglobin (60 g/L), hematocrit (0.18), and erythrocyte count (2.4 10). The normochromic blood film showed pencil cells, some elliptocytes, and erythrocyte fragments. Mass spectrometry confirmed a complete switch to an adult pattern of hemoglobin synthesis, with no significant amount of chains detected; the abnormal 15 157-Da chain was still present at a level of approximately 18% (Fig. 1). Isopropanol stability tests showed no precipitation at 30 min, and although a small amount of precipitate formed after the incubation was extended to 45 min, electrospray analysis showed no enrichment of the variant chain. This normal stability suggests that the mutation is benign; making it unlikely that it contributes to the hemolytic condition. This case highlights the importance of isolating the potential pathological effect of novel hemoglobin mutations when they are identified in association with changes in hemoglobin concentrations. In this case it appears the hemolysis is due to the accompanying, but unrelated, erythrocyte membrane defect.
منابع مشابه
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 53 9 شماره
صفحات -
تاریخ انتشار 2007