Assessment of Neuroinflammation in Transferred EAE Via a Translocator Protein Ligand
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Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL
Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Clinical severity and neuronal apoptosis in brainstem motor areas were substantially reduced upon brain-specific blockade of TRAIL after induction of EAE ...
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