Epinephrine and Tissue Permeability *

In a previous publication3 it was shown that spinal transection is followed by a pronounced reduction of tissue permeability.' Since it is known that spinal reflex centers for the liberation of epinephrine are located in the thoracic segment of the splnal cord,4 and since Favilli reported a reduction in skin permeability after.epinephrine injections, the question arose as to whether the liberation of this substance was a factor in the effects of spinal section. Accordingly, a series of experiments was instituted in an attempt to duplicate Favilli's results and to study the action of ergotamine tartrate on any epinephrine effects which might be observed. The effects of ibilateral adrenalectomy were also investigated.