Validation of a Murinic Model of Sepsis Induced by Cecal Ligation and Puncture Technique
نویسندگان
چکیده
Sepsis is considered to be a systemic response to an infection. This pathology is an common cause for mortality and morbidity being the primary cause of death among patients in the Intensive Care Units. Because of the increasing need for a standardised animal model of sepsis we decided to validate a murinic one using the cecal ligation and puncture (CLP) technique and easy to obtain physiologic and laboratory parameters.
منابع مشابه
A New Approach to Monitoring and Evaluation of Cecal Ligation and Puncture Sepsis Model
Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...
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