Hypoxia-Inducible Factor-1a (HIF-1a)Gene Polymorphisms,Circulating Insulin-LikeGrowth Factor Binding Protein (IGFBP)-3 Levels and ProstateCancer
نویسندگان
چکیده
Haojie Li,* Glenn J. Bubley, Stephen P. Balk, J. Michael Gaziano, Michael Pollak, Meir J. Stampfer, and Jing Ma Channing Laboratory,DepartmentofMedicine,BrighamandWomen’sHospitalandHarvardMedical School, Boston,Massachusetts DepartmentofMedicine,Beth Israel DeaconessMedical Center;HarvardMedical School, Boston,Massachusetts Divisionof PreventiveMedicine,BrighamandWomen’sHospitalandHarvardMedical School,Boston,Massachusetts MassachusettsVeterans Epidemiology Researchand InformationCenter (MAVERIC), VABostonHealthcare System,Boston,Massachusetts Cancer PreventionCentre,McGill University,Montreal,Canada Departmentsof EpidemiologyandNutrition,Harvard Schoolof PublicHealth,Boston,Massachusetts
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Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression.
Insulin-like growth factor binding protein 1 (IGFBP-1) is a hypoxia-inducible gene that plays an important role in regulating embryonic growth and development under hypoxic stress. The molecular mechanisms underlying hypoxia-induced IGFBP-1 gene expression in the embryonic tissues are not well understood. Here we report that the hypoxia-inducible factor 1 (HIF-1) pathway is established in early...
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