C12) United States Patent (54) Click Chemistry Surface Functionalization for Resonant Micro-cavity Sensors I Lllll Llllllll Ill Lllll Lllll Lllll Lllll Lllll 111111111111111111111111111111111

(57) ABSTRACT Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.