Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis.
نویسندگان
چکیده
The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.
منابع مشابه
بررسی نقش جهش‌های شایع ژن NOD2 در بیماری کرون
Abstract Background: NOD2 gene located on chromosome 16 (IBD1) is known to have a strong association with Crohn’s disease. Three common polymorphisms of this gene including R702W, G908R, 1007fsinsC, were reported to be frequent in many western populations while rare occurrence of them was observed in eastern countries. The aim of this study was to assess the frequency of these polymorphisms ...
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عنوان ژورنال:
- FEMS immunology and medical microbiology
دوره 41 2 شماره
صفحات -
تاریخ انتشار 2004