Septal urocortin 3 modulates stress-coping behaviour but not hypothalamic-pituitary-adrenal axis activity during forced swimming
نویسندگان
چکیده
Background The lateral septum (LS) has been shown to play an important role in the generation and modulation of behavioural and neuroendocrine stress responses. However, the exact neurochemical mechanisms mediating these effects are not well studied so far. Several lines of evidence suggest a robust contribution of septal urocortin 3 (UCN3) and its preferred receptor, the corticotropin-releasing factor type 2 (CRF2) receptor in mediating these effects. Therefore, the aim of the present study was to examine the role of septal CRF2 receptors in neuroendocrine and behavioural stress responses.
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