Ethanol induces the formation of water-permeable defects in model bilayers of skin lipids.
نویسندگان
چکیده
We show that ethanol can induce the formation of water-permeable defects in model membranes of skin, providing a fresh perspective on ethanol as a membrane modulator. We rationalise our findings in terms of the chemical nature of ethanol, i.e., a combination of its hydrogen bonding propensity and amphiphilic character.
منابع مشابه
The investigation of ionic association in the CdF2 solution with the mixed solvent (water +ethanol +propanol) at 25°C
Using the mixed solvents, (water +ethanol + propanol), the solubility of CdF2 was determined byevaporating method at 25° C. The results showed that the sollbility, s, of CdF2 decreases bydecreasing the dielectric constant of the mixed solvent .Once the solubility of CdF2 was determined,the concentration solubility product, Ksp(c)=4s3, was calculated .Furthermore ,by estimating the meanactivity ...
متن کاملMolecular Insight into the Mutual Interactions of Two Transmembrane Domains of Human Glycine Receptor (TM23-GlyR), with the Lipid Bilayers
Appearing as a computational microscope, MD simulation can ‘zoom in’ to atomic resolution to assess detailed interactions of a membrane protein with its surrounding lipids, which play important roles in the stability and function of such proteins. This study has employed the molecular dynamics (MD) simulations, to determine the effect of added DMPC or DMTAP molecules on the structure of D...
متن کاملAlpha-tocopherol inhibits pore formation in oxidized bilayers.
In biological membranes, alpha-tocopherols (α-toc; vitamin E) protect polyunsaturated lipids from free radicals. Although the interactions of α-toc with non-oxidized lipid bilayers have been studied, their effects on oxidized bilayers remain unknown. In this study, atomistic molecular dynamics (MD) simulations of oxidized lipid bilayers were performed with varying concentrations of α-toc. Bilay...
متن کاملDisturb or stabilize? A molecular dynamics study of the effects of resorcinolic lipids on phospholipid bilayers.
Resorcinolic lipids, or resorcinols, are commonly found in plant membranes. They consist of a substituted benzene ring forming the hydrophilic lipid head, attached to an alkyl chain forming the hydrophobic tail. Experimental results show alternative effects of resorcinols on lipid membranes. Depending on whether they are added to lipid solutions before or after the formation of the liposomes, t...
متن کاملSurface tension induced by sphingomyelin to ceramide conversion in lipid membranes.
We have investigated the effect of sphingomyelin (SM) to ceramide enzymatic conversion on lipid bilayers using Giant Unilamellar Vesicles (GUVs). Sphingomyelinase was added externally to GUVs containing various proportions of SM. In situ asymmetrical SM conversion to ceramide reduced the area of one leaflet. In the absence of equilibration of all the lipids between the two leaflets, a mismatch ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 51 25 شماره
صفحات -
تاریخ انتشار 2015