A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.

نویسندگان

  • Norifumi Shigemoto
  • Shizuo Kayama
  • Ryuichi Kuwahara
  • Junzo Hisatsune
  • Fuminori Kato
  • Hisaaki Nishio
  • Katsutoshi Yamasaki
  • Yasunao Wada
  • Taijiro Sueda
  • Hiroki Ohge
  • Motoyuki Sugai
چکیده

We investigated 5 metallo-β-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where blaIMP-34 is located on a transmissible plasmid.

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عنوان ژورنال:
  • Diagnostic microbiology and infectious disease

دوره 76 1  شماره 

صفحات  -

تاریخ انتشار 2013