nPKCε, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
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چکیده
Camille Ehre, Yunxiang Zhu, Lubna H. Abdullah, John Olsen, Keiichi I. Nakayama, Keiko Nakayama, Robert O. Messing, and C. William Davis Cystic Fibrosis/Pulmonary Research and Treatment Center, Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina; Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoda, Japan; and Ernest Gallo Clinic & Research Center, University of California-San Franciso, San Francisco, California
منابع مشابه
Mucin secretion and PKC isoforms in SPOC1 goblet cells: differential activation by purinergic agonist and PMA.
SPOC1 cells, which are a mucin-secreting model of rat airway goblet cells, possess a luminal P2Y2 purinoceptor through which UTP, ATP, and ATPgammaS stimulate secretion with EC50 values of approximately 3 microM. PMA elicits mucin secretion with high EC50 (75 nM) and saturation (300 nM) values. For the first time in airway mucin-secreting cells, the PKC isoforms expressed and activated by a sec...
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تاریخ انتشار 2007