Original article Impact of EGFR expression on colorectal cancer patient prognosis and survival

نویسندگان

  • J.-P. Spano
  • C. Lagorce
  • D. Atlan
  • G. Milano
  • J. Domont
  • R. Benamouzig
  • A. Attar
  • J. Benichou
  • A. Martin
  • J.-F. Morere
  • M. Raphael
  • F. Penault-Llorca
  • J.-L. Breau
  • R. Fagard
  • D. Khayat
  • P. Wind
چکیده

Département d’Oncologie Médicale, Hôpital Pitié-Salpétrière, Paris; Département d’Anatomopathologie, Hôpital Avicenne, Bobigny; Département de Radiothérapie et Statistique, Hôpital Européen Georges Pompidou, Paris; Département d’Oncopharmacologie, Centre Antoine Lacassagne, Nice; Département de Gastro-Entérologie, Hôpital Avicenne, Bobigny; Département de Chirurgie Viscérale, Hôpital Bobigny, Bobigny; Département d’Oncologie Médicale, Département d’Hématobiologie, Département de Biochimie et de Biologie Moléculaire, Hôpital Avicenne, Bobigny; Département d’Anatomopathologie, Centre Anticancéreux, Clermont-Ferrand, France

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Evaluation of Expression of EGFR, HER-2 and COX-2 in Colorectal Cancer

Background and objective: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer. Mater...

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Impact of EGFR expression on colorectal cancer patient prognosis and survival: a response.

We recently read the article from Spano et al. [1], which describes the impact of epidermal growth factor receptor (EGFR) detection on colorectal cancer patient survival. Although we found the study of some interest, we have some concerns. First, the authors affirm that previous studies did not demonstrate any influence of EGFR expression on patient survival and disease-free survival. In 2003 w...

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Letters to the Editor Impact of EGFR expression on colorectal cancer patient prognosis and survival: a response

We recently read the article from Spano et al. [1], which describes the impact of epidermal growth factor receptor (EGFR) detection on colorectal cancer patient survival. Although we found the study of some interest, we have some concerns. First, the authors affirm that previous studies did not demonstrate any influence of EGFR expression on patient survival and disease-free survival. In 2003 w...

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تاریخ انتشار 2004