Formulation and Evaluation of Fast Dissolving Tablets of Flunarizine HCl by Sublimation Method Using Treated Agar As Superdisintegrant

In the present work, Flunarizine hydrochloride, an anti-migraine drug has been formulated into fast dissolving tablets by sublimation method using camphor and menthol as sublimating agents and treated agar as superdisintegrant. Concentrations of the sublimating agents were varied keeping the concentration of superdisintegrant fixed. The aim of the study was to prepare fast dissolving tablets with better drug releasing profile. The comparative evaluation of selected concentrations of sublimating agents on various physico-chemical properties of tablets was performed. Wetting time, water absorption ratio, In-vitro disintegration time, and drug release was dependent on the concentration of sublimating agents. The fast dissolving tablets were prepared with 0%-26.5% concentration of sublimating agents with optimum concentration of 10% of treated agar. The blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and hausner’s ratio. The tablets were evaluated and compared for thickness, hardness, friability, weight variation, content uniformity, wetting time and water absorption ratio, In-vitro disintegration time, dissolution study and FTIR studies. The formulation F8 with 26.5% of menthol and 10% of treated agar was found to be best with a better drug release of 99.72% in 90 secs. We could conclude that, superdisintegrant, menthol was better compared to camphor.