Evaluation of Hepatoprotective Potential of Euphorbia Prostrata Ait Extract against Chemically Induced Hepatotoxicity in Albino Mice

Hepatic diseases are serious health issues as various pharmaceuticals, xenobiotics, environmental/chemical pollutants, some natural products and dietary supplements when used in overdose have tendency to cause hepatotoxicity. Present study was aimed at investigating hepatoprotective activity of aqueous methanolic extract of Euphorbia prostrata against paracetamol and carbon tetrachloride induced hepatotoxicity in mice, using silymarin as a standard drug. Hepatoprotective effects were accessed by investigating serum marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase), total bilirubin, albumin and total protein as well as histopathological analysis. Euphorbia prostrata exhibited significant reduction in serum marker enzymes at 250 mg/kg and 500 mg/kg doses. Moreover, histopathological studies also supported biochemical estimation. It could be concluded that aqueous methanolic extract of Euphorbia prostrata possesses hepatoprotective potential against carbon tetrachloride and paracetamol induced hepatic injury which might to due to anti-oxidant activity displayed by flavonoids and polyphenolics.