Loss of Rad - GTPase Produces a Novel Adaptive Cardiac Phenotype Resistant to 1 Systolic Decline with Aging 2 3 Janet
نویسندگان
چکیده
Janet R. Manning, Catherine N. Withers, Bryana Levitan, Jeffrey D. Smith, Douglas 4 A. Andres, Jonathan Satin 5 6 Department of Physiology, Department of Biochemistry, Gill Heart Institute, University 7 of Kentucky, Lexington KY 8 9 10 11 12 13 Short title: Rad-deletion improves heart function 14 15 16 17 18 19 20 Address for correspondence: 21 Jonathan Satin, PhD 22 Department of Physiology 23 University of Kentucky College of Medicine 24 800 Rose St 25 Lexington, KY 40536-0298 26 Email: [email protected] 27 Tel: 859.323.5356 28 29 Or 30 31 Douglas A. Andres, PhD 32 Department of Biochemistry 33 University of Kentucky College of Medicine 34 Lexington, KY 40536-0509 35 Email: [email protected] 36 Tel: 859.257.6776 37 Articles in PresS. Am J Physiol Heart Circ Physiol (September 14, 2015). doi:10.1152/ajpheart.00389.2015
منابع مشابه
Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.
Rad-GTPase is a regulator of L-type calcium current (LTCC), with increased calcium current observed in Rad knockout models. While mouse models that result in elevated LTCC have been associated with heart failure, our laboratory and others observe a hypercontractile phenotype with enhanced calcium homeostasis in Rad(-/-). It is currently unclear whether this observation represents an early time ...
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