Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene.
نویسندگان
چکیده
Recent investigations of chromosomal aberrations in chronic lymphocytic leukemia (CLL) led to a better understanding of the molecular causes of CLL. Here we report a rearrangement between MAML2 (mastermind-like protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation. The rearrangement between MAML2 and CXCR4, created by a t(2;11)(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the MAML2 gene. This fusion gene encodes for CXCR4/MAML2 protein chimera in which the N-terminal basic domain of MAML2 is replaced by the N-terminal domain of CXCR4.
منابع مشابه
Brief Report LYMPHOID NEOPLASIA Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene
Chronic lymphocytic leukemia (CLL) is the most common human leukemia representing ;30% of all leukemia cases. This disease occurs in 2 forms: aggressive and indolent; both forms are characterized by the clonal expansion of CD5-positive B lymphocytes. Genomic aberrations are detected in over 80% of CLL cases and numerous studies of lymphoid malignancies showed that chromosomal translocations oft...
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ورودعنوان ژورنال:
- Blood
دوره 124 2 شماره
صفحات -
تاریخ انتشار 2014