Passive transfer of experimental allergic thyriditis, delayed hypersensitivity to thyroglobulin and anti-thyroglobulin antibody formation in inbred Lewis rats.
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چکیده
منابع مشابه
The immune response against myelin basic protein in two strains of rat with different genetic capacity to develop experimental allergic encephalomyelitis
After challenge with guiena pig basic protein (GPBP) Lewis (Le) rats, which are homozygous for the immune response experimental allergic encephalomyelitis (Ir-EAE) gene, developed positive delayed skin tests against GPBP and the 43 residue encephalitogenic fragment (EF); in addition, Le rat lymph node cells (LNC) were stimulated and produced migration inhibitory factor (MIF) when incubated in v...
متن کاملThe Effect of 6-mercaptopurine and Aminopterin on Experimental Immune Thyroiditis in Guinea Pigs
The influence of 6-mercaptopurine and aminopterin was studied on immune response and immune thyroiditis in guinea pigs immunized with thyroid extract. 1. Both compounds depressed delayed hypersensitivity to thyroglobulin and immune thyroiditis. 2. Antibody formation to thyroglobulin was strongly depressed by aminopterin but not significantly influenced by 6-mercaptopurine. 3. Immune response an...
متن کاملCellular events in the induction of experimental allergic encephalomyelitis in rats
Although both the T and B cells of the Lewis rat have immunoglobulin receptors for basic protein (BP) of myelin, and both cell types are required for antibody production to BP, the present results demonstrate that the T cells are the only cells required for the induction of experimental allergic encephalomyelitis (EAE). Both EAE and anti-BP were readily induced in thymectomized, irradiated Lewi...
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The anti-allergic and anti-inflammatory activities of DS-4574, which possesses leukotriene antagonism and inhibits the release of immunologically stimulated mediators such as histamine and leukotrienes, were evaluated in several animal models. DS-4574 had dose-dependent inhibitory effects on IgE-mediated passive cutaneous anaphylaxis and the passive Arthus reaction in rats and the phase I respo...
متن کاملStrain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat.
BACKGROUND Previous studies have shown that different inbred rat strains vary in their susceptibility to experimental autoimmune glomerulonephritis (EAG). The Wistar Kyoto (WKY) rat is highly susceptible and develops crescentic glomerulonephritis, while the Lewis (LEW) rat is resistant. When immunized with collagenase-solubilized rat glomerular basement membrane (GBM), both strains produce circ...
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ورودعنوان ژورنال:
- Clinical and experimental immunology
دوره 5 1 شماره
صفحات -
تاریخ انتشار 1969