A Formal Catalytic Asymmetric Synthesis of (+)-Biotin with Modified Cinchona Alkaloids
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چکیده
Synthesis 2001, No. 11, 28 08 2001. Article Identifier: 1437-210X,E;2001,0,11,1737,1741,ftx,en;C03601ss.pdf. © Georg Thieme Verlag Stuttgart · New York ISSN 0039-7881 Abstract: A formal catalytic asymmetric synthesis of (+)-biotin was realized. The key steps involve a catalytic, highly enantioselective and quantitative desymmetrization of a meso cyclic anhydride followed by a one-pot chemoselective reduction to form the optically active lactone intermediate in the Goldberg–Sternbach (+)-biotin synthesis.
منابع مشابه
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تاریخ انتشار 2001