Chronic Periodontal Disease: A Proxy of Increased Cancer Risk

نویسندگان

  • Eunice Virtanen
  • Per-Östen Söder
  • Jukka H. Meurman
  • Leif C. Andersson
  • Birgitta Söder
چکیده

We investigated statistical association between long-term periodontal disease and cancer in a group of patients followed-up for 24 years with the hypothesis that chronic infection affects carcinogenesis. We made a prospective study of 1676 30-40-year old subjects in Stockholm, clinically examined in 1985. The data were combined with Swedish Cancer Registry in 2009. All cancer types were registered according to WHO International Classification of Diseases. Associations between cancer and dental parameters were studied using multiple logistic regression analysis with background variables and known risk factors for cancer. Age, gender, dental visits, education, income, socioeconomic status, working history, smoking, dental plaque, calculus, gingival bleeding, periodontal disease indicated by extracted or extruded molars were the independent variables. 286 subjects had periodontal disease in 1985. Of these, 18 subjects (6.3%) got cancer by 2009. In women breast cancer dominated (50%) while in men the types of malignancies were scattered. Logistic regression analysis showed that if a subject had periodontitis with extruded/extracted first molar tooth (d. 46) of the mandible in 1985, the risk of cancer increased with odds ratio (OR) 8.43, if the second molar (d. 47) was missing, OR for cancer was 6.11. To conclude chronic periodontal disease indicated by extracted or extruded molars associated statistically with elevated incidence of cancer. Keywords-Cancer, periodontal disease, oral infection, chronic infection, extracted molars, missing teeth.

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تاریخ انتشار 2013