Testicular failure
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چکیده
Testicular failure (TF) is referring to the condition of testicles which are unable to produce sperm or testosterone. Testosterone is the essential androgen (male sex hormone) for male reproductive function that allows for the development of male genitalia, secondary sex characteristics in prepubescent males, and the maintenance of secondary sex characteristics, initiation and maintenance of spermatogenesis (the sperm cell development), and stimulation and maintenance of sexual function in postpubescent males. Therefore, its low production causes decreased sperm production and change of the body aspect among other effects. Androgen deficiency in young prepubertal boys causes delayed puberty, decreased muscle mass and hair growth and prohibits the development of typical male deep voice etc. Testicular failure may manifest by reduced libido, sexual dysfunction (erectile dysfunction) in adolescent men. Any man with testosterone deficiency is in increased risk of osteoporosis.
منابع مشابه
FISH analysis of chromosome X, Y and 18 abnormalities in testicular sperm from azoospermic patients.
BACKGROUND Sperm extracted from testicular biopsies of azoospermic men can successfully be used for ICSI. The concern exists that testicular sperm from azoospermic men suffering from severe testicular failure may have a higher frequency of aneuploidy, which may lead to an increased risk for chromosomally abnormal offspring. METHODS Testicular sperm from patients showing spermatogenic failure ...
متن کاملComparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility
We assessed the rates of sperm retrieval and intracytoplasmic sperm injection outcomes, including the neonatal profile of infants conceived, in men with testicular failure. Three-hundred and sixty-five men with testicular failure who underwent micro-dissection testicular sperm extraction were included in this study. We compared their outcomes with 40 men with testicular failure who used donor s...
متن کاملCystic fibrosis gene mutations and infertile men with primary testicular failure.
It has been proposed that the gene responsible for cystic fibrosis, called the cystic fibrosis transmembrane conductance regulator (CFTR) gene, may play an important role in the process of spermatogenesis. A group of azoospermic men with primary testicular failure underwent CFTR mutation analysis, including assessment of the intron 8 polythymidine tract (IVS8-T tract). An association was not fo...
متن کاملMale Hypogonadism — Symptoms and Diagnosis
Male hypogonadism is a condition characterized by decreased testosterone production and sperm quality or production. This can be the result of primary testicular failure or secondary testicular failure due to pituitary or hypothalamic disorders. Symptoms of hypogonadism include erectile dysfunction, decreased libido, and regression or absence of secondary sexual characteristics. Total testoster...
متن کاملHypogonadism — Symptoms and Diagnosis
Male hypogonadism is a condition characterized by decreased testosterone production and sperm quality or production. This can be the result of primary testicular failure or secondary testicular failure due to pituitary or hypothalamic disorders. Symptoms of hypogonadism include erectile dysfunction, decreased libido, and regression or absence of secondary sexual characteristics. Total testoster...
متن کاملHypogonadism — Symptoms and Diagnosis
Male hypogonadism is a condition characterized by decreased testosterone production and sperm quality or production. This can be the result of primary testicular failure or secondary testicular failure due to pituitary or hypothalamic disorders. Symptoms of hypogonadism include erectile dysfunction, decreased libido, and regression or absence of secondary sexual characteristics. Total testoster...
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