Lysine peptides induce lipid intermixing but not fusion between phosphatidic acid-containing vesicles
نویسندگان
چکیده
Penta(L-lysine) and poly(L-lysine) (but not dior tri(-L-lysine)) were found to induce rapid and extensive phospholipid intermixing between unilamellar vesicles consisting largely of phosphatidic acid and phosphatidylethanolamine, without causing significant intermixing of, nor leakage from, the encapsulated aqueous spaces. Neither did the size of such vesicles increase after treatment with lysine peptide, as determined by gel chromatography. The results suggest that lysine oligo(or poly-) peptides may induce reversible semifusion between vesicles, but not complete membrane fusion.
منابع مشابه
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