Supernumerary Philadelphia Positive

نویسندگان

  • Nivedita Pathak
  • Akhilesh Mishra
چکیده

Philadelphia chromosome is observed in 25-50% of adult Acute Lymphoblastic Leukemia (ALL) cases and in about 5% of childhood ALL cases. A hyper diploid karyotype, defined by the presence of more than 46 chromosomes, is detected in 2-9% of adult ALL patients and in 29% of pediatric patients [1]. Translocation t (9; 22) or Philadelphia chromosome is a common structural aberration found in patients, who present with hyper diploidy [2,3]. It is conceivable that the simultaneous presence of additional karyotypic abnormalities may alter the biological properties of Ph+ cells and influence clinical outcomes [4]. In this context, the coexistence of a high-hyper diploid (53 chromosomes) karyotype with double Ph+ chromosomes is of interest since high-hyper diploidy as the sole cytogenetic abnormality in ALL is associated with a good prognosis [4], while Philadelphia positivity confers a worse prognosis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), an...

متن کامل

Characterization of four human YAC libraries for clone size, chimerism and X chromosome sequence representation.

Four collections of human X-specific YACs, derived from human cells containing supernumerary X chromosomes or from somatic cell hybrids containing only X human DNA were characterized. In each collection, 80-85% of YAC strains contained a single X YAC. Five thousand YACs from the various libraries were sized, and cocloning was assessed in subsets by the fraction of YAC insert-ends with non-X seq...

متن کامل

The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation (FISH).

INTRODUCTION Chronic myeloid leukaemia (CML) is characterised by the formation of the BCR/ABL fusion gene, usually as a result of the Philadelphia (Ph) translocation between chromosomes 9 and 22. MATERIALS AND METHODS The incidence of both typical and atypical BCR/ ABL gene rearrangements was determined in 110 patients suspected of CML using dual fusion fluorescence in situ hybridisation (DF-...

متن کامل

Interphase cytogenetic analysis of prostatic carcinomas by use of nonisotopic in situ hybridization.

To gain a better understanding of chromosomal aberrations in direct correlation with histology, we studied tumor material from 35 patients (36 regions) with primary prostate carcinoma by nonisotopic in situ hybridization. Nine biotinylated DNA probes were used on serial paraffin sections (centromer-specific probes for X, Y, 1, 7, 8, 10, 17, and 18, and a telomer-specific probe for 1p; ONCOR). O...

متن کامل

Inverted Supernumerary Intranasal Teeth as Unusual Indications of Endoscopic Surgery

Introduction: Supernumerary teeth are frequently reported in dental clinical practice; however, eruption in nasal cavities and paranasal sinuses is an extremely rare clinical entity.   Case Report: We report two cases with a history of recurrent nasal discharge and obstruction. In both cases, clinical and radiological findings confirmed the presence of an inverted supern...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017