STUDIES ON BLOOD FACTORS RhA, RhB, AND RhC
نویسندگان
چکیده
Observations are described of the incidence among Caucasians and Negroes of the blood factors Rh(A), Rh(B) and Rh(C) which occur associated with the Rh(0) factor in typical Rh-positive blood. The antiserums used for the tests were derived from Rh-positive patients who had had hemolytic transfusion reactions or erythroblastotic babies. Among a large series of individuals, it was found that only rarely is any of the blood factors Rh(A), Rh(B), or Rh(C) lacking from "standard" Rh(0)-positive blood. On the other hand, about half of the specimens of Rh(0) variant blood lack one or more of the factors Rh(A), Rh(B), and Rh(C), which, when present in such blood, are also almost always variants. Judging from the incidence of specimens lacking one or more of these factors, Rh(A), Rh(B), and Rh(B) appear to be relatively independent of one another despite their association with blood factor Rh(0). Tests for factors Rh(A), Rh(B), and Rh(C) distinguish new rare varieties of Rh and Reh agglutinogens, each genetically determined by corresponding allelic genes. There is no doubt that more clinical cases will be found in which sensitized Rh-positive individuals have antibodies resembling anti-Rh(0) in specificity. Four such cases have already been studied by the present authors, and in each case the antibodies were shown to be different from anti-Rh(0) in specificity. Since they were also different from one another, they have been assigned the symbols anti-Rh(A), anti-Rh(B), anti-Rh(C), and anti-Rh(D), respectively, the first three being the antiserums used in the present study. Obviously, in order to avoid confusion of nomenclature, the specificity of antiserums from other similar cases will have to be compared with anti-Rh(A), anti-Rh(B), anti-Rh(C), and anti-Rh(D) and shown to be different from all four, as well as anti-Rh(0), before a distinctive symbol is assigned to them.
منابع مشابه
Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule.
Rh glycoproteins are members of the ammonium transporter (Amt)/methylamine permease (Mep)/Rh family facilitating movement of NH(3) across plasma membranes. Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external an...
متن کاملGains from diversification on convex combinations: A majorization and stochastic dominance approach
By incorporating both majorization theory and stochastic dominance theory, this paper presents a general theory and a unifying framework for determining the diversification preferences of risk-averse investors and conditions under which they would unanimously judge a particular asset to be superior. In particular, we develop a theory for comparing the preferences of different convex combination...
متن کاملImproved immunogenicity of tetanus toxoid by Brucella abortus S19 LPS adjuvant.
BACKGROUND Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram negati...
متن کاملSteady electrodiffusion in hydrogel-colloid composites: macroscale properties from microscale electrokinetics.
A rigorous microscale electrokinetic model for hydrogel-colloid composites is adopted to compute macroscale profiles of electrolyte concentration, electrostatic potential, and hydrostatic pressure across membranes that separate electrolytes with different concentrations. The membranes are uncharged polymeric hydrogels in which charged spherical colloidal particles are immobilized and randomly d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 110 شماره
صفحات -
تاریخ انتشار 1959