Pneumocystis jiroveci Dihydropteroate Synthase Gene Mutations at Codon 171 but Not at Codons 55 or 57 Detected in Germany Sir—After the introduction of HAART and of trimethoprim-sulfamethoxazole (TMP-SMZ) for Pneumocystis pneumonia
نویسنده
چکیده
NOTE. PR, present report; TMP-SMZ, trimethoprim-sulfamethoxazole. in Missouri and other areas where the disease is not endemic needs review. The national Lyme disease surveillance case definition was developed nearly 10 years ago [3], and a great amount of relevant new scientific evidence regarding Lyme disease and southern tick–associated rash illness has accumulated since that time. The findings of Wormser et al. [6, 9] argue in favor of establishing more rigorous inclusion criteria for patients who present with erythema migrans–like lesions in areas where Lyme disease is not endemic.
منابع مشابه
Study of dihydropteroate synthase (DHPS) gene mutations among isolates of Pneumocystis jiroveci.
BACKGROUND & OBJECTIVES Pneumocystis jiroveci (also known as P. carinii) causes fatal pneumonia in patients with AIDS and other immunocompromised patients. Co-trimoxazole (trimethoprim + sulphamethoxazole, TMP-SMZ) is the drug of choice for treatment and prophylaxis. Widespread use of sulpha medication has raised the possible selection of resistant P. jiroveci strains worldwide. Non-synonymous ...
متن کاملPrevalence of dihydropteroate synthase mutants in HIV-infected South African children with Pneumocystis jiroveci pneumonia.
BACKGROUND Pneumocystis jiroveci (formerly Pneumocystis carinii) pneumonia (PCP) is a major cause of mortality in human immunodeficiency virus (HIV)-infected infants in Africa, but the prevalence of mutations in the gene encoding dihydropteroate synthase (DHPS) in isolates from Africa has not been reported. METHODS This study investigated the prevalence of DHPS mutations in P. jiroveci isolat...
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A 50-year-old male visited the outpatient clinic and complained of fever, poor oral intake, and weight loss. A chest X-ray demonstrated streaky and fibrotic lesions in both lungs, and chest CT revealed multifocal peribronchial patchy ground-glass opacities with septated cystic lesions in both lungs. Cell counts in the bronchoalveolar lavage fluid revealed lymphocyte-dominant leukocytosis, and f...
متن کاملDihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis. While prophylaxis has reduced the incidence of PCP, its use has raised concerns about development of resistant organisms. The inability to culture human Pneumocystis, Pneumocystis jirovec...
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Pneumocystis pneumonia (PCP) is an opportunistic infection that occurs in humans and other mammals with debilitated immune systems. These infections are caused by fungi in the genus Pneumocystis, which are not susceptible to standard antifungal agents. Despite decades of research and drug development, the primary treatment and prophylaxis for PCP remains a combination of trimethoprim (TMP) and ...
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