Stabilisation of metastable polymorphs: the case of paracetamol form III.
نویسندگان
چکیده
The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising 'active' templates of the metastable polymorph.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 81 شماره
صفحات -
تاریخ انتشار 2016