Effects of slime produced by clinical isolates of coagulase-negative staphylococci on activities of various antimicrobial agents.
نویسندگان
چکیده
A novel in vitro semiquantitative method was developed to investigate the influence of staphylococcal slime on the activities of 22 antimicrobial agents. Pefloxacin, teicoplanin, and vancomycin demonstrated remarkable decreases in efficacy: 30, 52, and 63%, respectively. The activity of rifampin was not significantly reduced (0.99%), whereas all other agents tested were modestly affected (<15% decrease). These data could be influential in the treatment of implant-associated infections caused by slime-producing staphylococci.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 42 4 شماره
صفحات -
تاریخ انتشار 1998