The Puerto Rico oral contraceptive study : An evaluation of the methodology and results of a feasibility study
نویسندگان
چکیده
Sumnary The Puerto Rico oral contraceptive study, hegun in 1961, was thefirst attempt to evahate the longterm satfety of oral co/itraceptilves (OCs'). II addition, it was the on/v large-scale sttdal' employin,' rando//isatioi of'healthv subjects into OC and non-OC groups. tI/ma/ncial support ended in 1976. In 1979, the International Flerti/it' Research Proqra/nt (IFRP) ul/ndertook a.easibilityv .;tutti to assess the vahe of res h/III/the prorj'cts.liding. The sYste/natic sampe was ge/lerd/.' repr'sentative o/the originalcohort. Ony 245 per cent of the 212 patients in the.feasibilit)y sample had beei active (visited the clinic) i/ the last si. months o' 1976. Mo,-e than haf of i/clo/g-te:'m users (too years or more of their ass ,ned contraceptive) were not active iv 1976. 1 pilot held sttui(.' estiualed that approxi/natel'v half f/' those inacive in 1976 could he located. It is conchued that loss io follow-up and lack offl inormation 0/ co/ntraceptive usage are too great to restart the project as ori,inall conceived,
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