Light-activatable molecular beacons with a caged loop sequence.
نویسندگان
چکیده
We have synthesized molecular beacons with caged nucleobases in the loop region. These constructs remain non-fluorescent in the presence of their target RNA but can be fully activated by light (366 or 405 nm) in vitro and in HEK293 cells. We suggest that this technology will be useful for single molecule RNA tracking in living cells.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 22 شماره
صفحات -
تاریخ انتشار 2012