Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway.

نویسندگان

  • Nozomi Hisada
  • Hideo Satsu
  • Akira Mori
  • Mamoru Totsuka
  • Jun-ichi Kamei
  • Takashi Nozawa
  • Makoto Shimizu
چکیده

The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.

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عنوان ژورنال:
  • Bioscience, biotechnology, and biochemistry

دوره 72 4  شماره 

صفحات  -

تاریخ انتشار 2008