Computer Modeling of JAK/STAT Signal Transduction Pathway
نویسندگان
چکیده
Cytokines regulate important cellular responses through signal transduction pathways. The computer modeling is a useful method to understand dynamic characteristics or regulatory mechanisms of signal transduction pathways. The ultrasensitivity of the mitogen-activated protein kinase cascade was shown by the simulation study [2]. Many cytokine receptors transduce signals by receptor bound JAK kinase. JAK/STAT pathway is one of main signal transduction pathways initiated by cytokines. SOCS1, which is induced by JAK/STAT pathway, binds JAK and inhibits its kinase activity [4]. To understand the regulatory mechanisms by induced SOCS1, we developed the model of JAK/STAT pathway and investigated its dynamics by the computer simulation.
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