The urology perspective on expanding androgen-targeted treatments for men with castration-resistant prostate cancer.

This is an exciting time for physicians who care for patients with advanced prostate cancer, and more importantly a time of heightened optimism for these men and their families. Since 2010, six new agents have been approved by the US Food and Drug Administration (FDA) for castrate-resistant prostate cancer (CRPC), including sipuleucel-T, cabazitaxel, abiraterone acetate, denosumab, enzalutamide, and radium-223.[1] With the exception of cabazitaxel, all of these agents are commonly available for both urologists and oncologists to prescribe. In particular, the new oral hormonal agents are especially appealing for urology use given that urologists have been on the forefront of androgen deprivation therapy (ADT) for more than 75 years.[2]