A global strategy for prevention and detection of blood doping with erythropoietin and related drugs.
نویسنده
چکیده
The definition blood doping was introduced by the media in the 1970s to describe the use of blood transfusion to increase red cell mass artificially, and in turn to enhance both maximal oxygen uptake and performance in endurance sports. Since the late 1980s blood doping is no longer achieved by autologous transfusion but instead through administration of recombinant human erythropoietin (rHuEpo).
منابع مشابه
rHuEpo administration in patients with low-risk myelodysplastic syndromes: evaluation of erythroid precur-
controlled trial of recombinant human erythropoietin, epoetin beta, in hematologic malignancies. J Clin Oncol 2002;20: 2486-94. 12. Cazzola M, Beguin Y, Kloczko J, Spicka I, Coiffier B. Onceweekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin production. Br J Haematol 2003, in press. 13. Pangalis GA, Sia...
متن کاملProduction of Erythropoietin-specific polyclonal Antibodies
Background: Erythropoietin, as a principal hormone promotes red blood cell production in bone marrow. Varieties of erythropoietin biosimilar are being produced by recombinant DNA technology in cell cultures. The detection or quantification of these molecules are being performed by diff erent methods which some of theme such as Western blot and enzymelinked immunosorbent assay (ELISA) require sp...
متن کاملDrugs of abuse and the adolescent athlete
Doping with endocrine drugs is quite prevalent in amateur and professional athletes. The World Anti-Doping Agency (WADA) has a list of banned drugs for athletes who compete and a strategy to detect such drugs. Some are relatively easy, anabolic steroids and erythropoietin, and others more difficult, human growth hormone (rhGH) and insulin like growth factor I (IGF-I). The use of such compounds ...
متن کاملRecombinant Human Erythropoietin in Children with Solid Tumors and Chemotherapy-induced Anemia
Background: In patients undergoing chemotherapy for cancer, anemia is part of the progression of the disease. Considering the effects of anemia on quality of life of the patients, the prevention and treatment of chemotherapy-induced anemia is crucial. This study was aimed to evaluate the efficacy of recombinant human erythropoietin in reducing the need for blood transfusion in children with sol...
متن کاملEmerging drugs--potential for misuse in sport and doping control detection strategies.
Preventive doping research includes the development of methods for the detection of new or emerging drugs to be implemented in routine screening analysis. Candidates with great potential for misuse in elite sports include selective androgen receptor modulators, growth hormone secretagogues, hypoxia-inducible factor stabilizers and erythropoietin mimetics.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 85 6 شماره
صفحات -
تاریخ انتشار 2000