Meta-analysis of myeloperoxidase gene polymorphism and coronary artery disease susceptibility.
نویسندگان
چکیده
OBJECTIVE To assess the association between myeloperoxidase (MPO) gene polymorphism and coronary artery disease (CAD). METHODS Several databases were used to retrieve relevant literature up to March 2013 by keywords. A Meta-analysis was performed by Stata12.0 software to estimate the pooled odds ratio (OR) and the 95% confidence interval (CI). Heterogeneity among studies was tested and sensitivity analysis was applied. Publication bias was examined using Begg's funnel plot and Egger's linear regression test. RESULTS A total of 17 studies were included in this Meta-analysis. For MPO -463 G/A polymorphism, the pooled OR of A allele vs G allele was 0.58 [95% CI (0.47-0.72)] and the pooled OR of genotypes AA+AG vs GG was 0.58 [95% CI (0.46-0.72)]. In subgroup analysis of study population, AA and AG genotypes were significantly associated with CAD in Asians but not in Europeans. The MPO -463 G/A polymorphism in the stable angina pectoris subgroup was evaluated in 3 studies and the pooled OR of A allele vs G allele and genotypes AA+AG vs GG for proven CAD was 0.45 [95% CI (0.15-1.37)] and 0.57 [95% CI (0.19- 1.65)]. For MPO -129 A/G gene polymorphism, the pooled OR of genotype GG vs AA+AG was 0.91 [95% CI (0.74-1.10)]. CONCLUSION A allele of MPO -463 G/A gene is associated with decreased risk of CAD except in the Europeans. There is no association between MPO -129 A/G gene polymorphisms and CAD risk.
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Myeloperoxidase G-463A polymorphism and coronary artery disease susceptibility in the Chinese population: an updated meta-analysis and review
Objective: Although a number of studies have been conducted on the association between myeloperoxidase (MPO) G-463A polymorphism and coronary artery disease (CAD), this association remains elusive and controversial. To assess the effects of MPO G-463A polymorphism on the risk of CAD in the Chinese population, an updated meta-analysis was performed. Methods: Related studies were identified from ...
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ورودعنوان ژورنال:
- Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
دوره 39 3 شماره
صفحات -
تاریخ انتشار 2014