5 Sinning.indd
نویسندگان
چکیده
High-grade gliomas are highly vascularized tumors. Neo-angiogenesis plays a key role in tumor growth and resistance to therapy. A cerebrospinal fl uid (CSF) sample could be a useful way to obtain pro-angiogenic predictive or prognostic markers at diff erent stages of the disease. As a fi rst step we looked for pro-angiogenic activity in the CSF of patients with high-grade gliomas. We performed the chicken embryo chorio-allantoic membrane (CAM) assay to study the angiogenic potential of the cerebrospinal fl uid (CSF), obtained either by lumbar puncture (LP) or craniotomy from six patients with high-grade brain tumors (three glioblastoma (WHO grade IV), one anaplastic oligodendroglioma (WHO grade III), two anaplastic ganglioglioma (WHO grade III)), and four healthy controls. Signifi cantly increased neo-angiogenesis was observed on the surface of the growing CAM in the 6 patients with high-grade gliomas compared to controls (3.69 ± 1.23 versus 2.16 ± 0.97 capillaries per area (mean ± SD), p<0.005). There was no statistical diff erence related to the hystological grade of the tumor (WHO grade III or IV), previous treatment (radio-chemotherapy plus temozolomide, temozolomide alone or no treatment), or the site of CSF sample (surgery or lumbar puncture). Our results suggest a pro-angiogenic potential in the CSF of patients with high-grade gliomas.
منابع مشابه
(P\351rez Ariza, C. \(2007\). El ...)
9 ! -. :/5. / / / 5 2 ) / 3/ ) 1 . 5 / 5/ . . . 1 2 0 5 4 5 . . / 1 . . ; 5 / . / . 4 : / 5/ . 1 . / 0 ) : / . 4 . : 45 <5 /0 . / / . 4 ) ; 4 <5 / ; 5 = 5 3. 0 / 1 . .5/ 0 <5 . . 1> . / . ) > . 7 0 / ; /5 . 4 . 5 .) . . / / . 4 . 3 4 ; 51. / / . ? . ! = / 5 . / / 5/ . . <5 . . 1 2 0 ? ) . :/5. . 5 . 2 0 1 . / ; . 7 ' ) . 5 5 1> <5 ) 7 0 / ) 7 15 . 45 . 5 5 /5 1 . 5 / . . 1 2 0 , 5 <5 7 / 1 ; 45...
متن کاملRe: Cycle - A Generative Ambient Video Engine
!"#$%&'", *), ', 4!/!('5*-!, '93*!/5, -*.!%, '(5, +*!#!, 3')!., %/, /'52(!, *9'4!(1, #'+52(!., */, 5$! 8'/'.*'/,K%#G1,I%2/5'*/);,>93*!/5,-*.!%,*),.!)*4/!.,5%,+&'1,*/,5$!,3'#G4(%2/.,%7,%2(,&*-!);,>/ '93*!/5,-*.!%,:%(G,*),.*77*#2&5,5%,#(!'5!,<,*5,#'/,/!-!(,(!P2*(!,%2(,'55!/5*%/0,325,92)5,'&:'1),(!:'(.) '55!/5*%/,:$!/,%77!(!.;,>,#!/5('&,'!)5$!5*#,#$'&&!/4!, 7%(, 5$*), 7%(9, *), 5$'5, *5,92)5,'&)%,...
متن کاملCross Reduction for Orthogonal Circuit Visualization
! " # $ % &' & #( & ) &' &' ' * ,+-& .* / * 10324 $ 5. &6 7 8 9 .*&:+-&'; . < / =: & >$ 5 &? ( .*( ;@>$ @=8. # (5 & & & $ # < ' ' 5 ? ( 7 A7 B(C / 5 3 D +-&' E # 5+/ 0GF =$H +# A?; .I J 5 K & +L M J. # 5() <(C="&' . # (N E 5 ' & A7( &' &8 5 C+ &' O &D 5 & ' & + K$=% E # .*($ O & HP 5+Q 5 C+-& O & $ & +% % ,AR =! ( R ! ! '& S ( & ' 5.* 7 T (5&' &O 5& 0 U@ : (5 T 5 "&' H AR&V *+ +& T ( &S *K &' W...
متن کاملAnalysis of Component-Based Systems – An Automated Theorem Proving Approach
! " $#% & ')(* +) , & . 0/ 1 +% 2) 3 546 7% 870 & 5 0 9 3 8 + : 20 / % ; & < >= ?6+% & $ 5#0#% @+A ) 5 0 & +) 5 ) 5 & & 8 BC<5 & 52) D E#0 5# & F 2 @+G 6BH2% ) D & I 5 ( % & B> D & J() 6 D F I *< * & 8 6 3 67% < / 5#) % (I + 2) ) 5 0 B> 7% & 5 9 B $46 & +AB> 46 7% & 5 -K) 54C =L M & D M D N M# BO 78 6<5 & 2 6 & < & M 5B & 5=QP) 5 3 $ & & Q & & * (; 5 ) 5 & & R2 ) AB> D @+% 0 &: 2 & +% & +% & 9#...
متن کاملSupplement to Internally 4-connected projective-planar graphs
A5 = {{1, 2}, {1, 3}, {1, 4}, {1, 5}, {2, 3}, {2, 4}, {2, 5}, {3, 4}, {3, 5}, {4, 5}, {6, 7}, {6, 8}, {6, 9}, {6, 10}, {7, 8}, {7, 9}, {7, 10}, {8, 9}, {8, 10}, {9, 10}} C11 = {{1, 2}, {1, 3}, {1, 4}, {1, 5}, {2, 3}, {2, 4}, {2, 5}, {3, 4}, {3, 5}, {4, 5}, {6, 9}, {6, 10}, {6, 11}, {7, 9}, {7, 10}, {7, 11}, {8, 9}, {8, 10}, {8, 11}} E42 = {{1, 4}, {1, 5}, {1, 6}, {2, 4}, {2, 5}, {2, 6}, {3, 4},...
متن کامل