Comprehensive Multiplexed Therapy for Severe Nodulocystic Acne in Puberty
نویسنده
چکیده
Nodulocystic acne (NCA) usually develops subcutaneous epidermal cyst, granuloma, subcutaneous abscess, hypertrophic scar, keloids, and draining sinus. The pathogenesis of NCA is still unclear. Similar to NCA, acne conglobata (AC) is found in men predominantly with oily skin [1]. Lesions of AC begin in early puberty and culminate in late adolescent [1]. AC is one of the most therapy-resistant diseases which do not respond to usual treatments for acne vulgaris. In Europe and USA, isotretinoin has been used for the treatment for NCA and AC [2]. However, it is unavailable to use in Japan. Therefore, treatment for NCA in Japan is very difficult. Two cases with NCA have been treated with comprehensive therapy with incision, oral and topical antimicrobials, oral tranilast, topical benzoyl peroxide (BPO) and skin care.
منابع مشابه
Nodulocystic acne and hidradenitis suppurativa treated with acitretin: a case report.
Nodulocystic acne is a dermatologic disease that can result in significant damage to the skin of the face, chest, and back. Hidradenitis suppurativa is a scarring disease of the skin that causes deep cysts and abscesses on the axillae and anogenital areas. We review a case of a patient with severe nodulocystic facial acne and hidradenitis suppurativa that was treated with 2 full courses of isot...
متن کاملEffects of Oral Isotretinoin on Serum Vitamin D Metabolites and Other Biochemical Markers of Bone Turnover and Calcium Homeostasis in Severe Acne
Background: Few studies have investigated on vitamin D metabolites Serum levels, and calcium homeostasis in humans receiving retinoids, despite a substantial amount of literature concerning retinoid-induced osteoporosis in animals. We prospectively measured vitamin D metabolites serum levels and calcium homeostasis and radiographic bone changes in short course treatment with oral isotreti...
متن کاملCostello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her ne...
متن کاملManagement strategies for acne vulgaris
CLINICAL QUESTION What are the most effective treatment(s) for mild, moderate, severe, and hormonally driven acne? RESULTS Mild acne responds favorably to topical treatments such as benzoyl peroxide, salicylic acid, and a low-dose retinoid. Moderate acne responds well to combination therapy comprising-topical benzoyl peroxide, antibiotics, and/or retinoids, as well as oral antibiotics in refr...
متن کاملEvaluation of the gastrointestinal findings of nodulocystic acnepatients during systemic isotretinoin therapy.
BACKGROUND/AIM Systemic isotretinoin treatment is an effective treatment modality for nodulocystic acne, the clinical use of which has been associated with reports of adverse events. We conducted a prospective study with the aim of determining the possible gastrointestinal and laboratory findings of nodulocystic acne patients during systemic isotretinoin treatment. MATERIALS AND METHODS Seven...
متن کامل