Etomoxir-induced PPARa-modulated enzymes protect during acute renal failure
نویسندگان
چکیده
DIDIER PORTILLA,1 GONGHE DAI,1 JEFFREY M. PETERS,3 FRANK J. GONZALEZ,3 MARK D. CREW,4 AND ALAN D. PROIA2 1Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205; 2Department of Pathology, Duke University Medical Center Durham, North Carolina 27710; 3Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892; and 4Department of Geriatrics, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205
منابع مشابه
Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure.
Regulation of fatty acid beta-oxidation (FAO) represents an important mechanism for a sustained balance of energy production/utilization in kidney tissue. To examine the role of stimulated FAO during ischemia, Etomoxir (Eto), clofibrate, and WY-14,643 compounds were given 5 days prior to the induction of ischemia/reperfusion (I/R) injury. Compared with rats administered vehicle, Eto-, clofibrat...
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تاریخ انتشار 2000