Glanders.

JAVMA, Vol 233, No. 4, August 15, 2008 G is a highly contagious bacterial disease of horses, mules, and donkeys that is characterized by respiratory, cutaneous, and lymphatic nodular lesions. The disease is zoonotic, affecting persons in close contact with infected animals or those working with the organism in laboratory settings. Once prevalent worldwide, glanders has been eradicated from most countries; however, focal outbreaks do still occur. Burkholderia mallei, the causative organism of glanders, is considered a potential bioterrorism agent and has been used historically for this purpose. Control and prevention measures for glanders involve evaluation of susceptible equids, quarantine measures, depopulation of infected animals, and disinfection of premises and equipment. Awareness of the disease and collaboration between veterinary and human health professionals is essential for the early detection and protection of equids and humans.