Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition.
نویسندگان
چکیده
Chronic musculoskeletal pain has biological, psychological and social components. This review deals with the biological factors, with emphasis on the fibromyalgia syndrome (FMS). Studies on central sensitization of pain-transmitting neurons, changes in endogenous pain modulation that give rise to pain disinhibition, referred pain, pain-related decrease in muscle strength and endurance, and pain generators in deep tissues are reviewed. In FMS there is strong scientific support for the statement that the biological part of the syndrome is a longstanding or permanent change in the function of the nociceptive nervous system that can be equated with a disease. Further research is necessary in order to determine which methods are best for diagnosis of the pain hypersensitivity in clinical practice. FMS may be the far end of a continuum that starts with chronic localized/regional musculoskeletal pain and ends with widespread chronic disabling pain.
منابع مشابه
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متن کاملReply to Quintner and Cohen.
I thank Drs. Quintner and Cohen for their interest in my editorial [1] about the study by Albrect et al. [2]. Drs. Quintner and Cohen have raised several concerns about my discussion of the implications of that study, especially of the concept that peripheral nociception by myofascial trigger points initiates central sensitization. They object to the idea that peripheral nerve sensitization is ...
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ورودعنوان ژورنال:
- Best practice & research. Clinical rheumatology
دوره 21 3 شماره
صفحات -
تاریخ انتشار 2007