DNA from fecal immunochemical test can replace stool for microbiota-based colorectal cancer screening
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چکیده
17. CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract 18 Background: There is a significant demand for colorectal cancer (CRC) screening 19
منابع مشابه
DNA from fecal immunochemical test can replace stool for detection of colonic lesions using a microbiota-based model
BACKGROUND There is a significant demand for colorectal cancer (CRC) screening methods that are noninvasive, inexpensive, and capable of accurately detecting early stage tumors. It has been shown that models based on the gut microbiota can complement the fecal occult blood test and fecal immunochemical test (FIT). However, a barrier to microbiota-based screening is the need to collect and store...
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Screening has a central role in colorectal cancer (CRC) control. Different screening tests are effective in reducing CRC-specific mortality. Influence on cancer incidence depends on test sensitivity for pre-malignant lesions, ranging from almost no influence for guaiac-based fecal occult blood testing (gFOBT) to an estimated reduction of 66-90% for colonoscopy. Screening tests detect lesions in...
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The annual guaiac or immunochemical fecal occult blood test (FOBT) is one of the five colorectal cancer (CRC) screening regimens recommended by the American Cancer Society (Smith, Cokkinides, & Eyre, 2005). Stool-based deoxyribonucleic acid (DNA) testing for CRC is considered a promising technology (Smith, Cokkinides, & Eyre, 2003). Numerous features of three noninvasive stool tests for CRC are...
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BACKGROUND Colorectal cancer screening and treatment are rapidly evolving. Aims To reappraise stool-based colorectal cancer screening in light of changing test performance characteristics, lower test cost and increasing colorectal cancer care costs. METHODS Using a Markov model, we compared faecal DNA testing every 3 years, annual faecal occult blood testing or immunochemical testing, and col...
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BACKGROUND Screening for colorectal cancer (CRC) and precancerous colorectal adenoma (CRA) can detect curable disease. However, participation in colonoscopy and sensitivity of fecal heme for CRA are low. METHODS Microbiota metrics were determined by Illumina sequencing of 16S rRNA genes amplified from DNA extracted from feces self-collected in RNAlater. Among fecal immunochemical test-positiv...
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