Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction.

Inhibition of Rho A activity causes pemphigus skin blistering

The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that PV-immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling. In vitro, pemphigus IgG caused typical hallmarks of pemphigus pathogenesis such as epidermal blister...

The IgG "lupus-band" deposition pattern of pemphigus erythematosus: association with the desmoglein 1 ectodomain as revealed by 3 cases.

BACKGROUND Pemphigus foliaceus is an autoimmune skin disease characterized by subcorneal blistering and IgG antibodies directed against desmoglein 1. In the skin, these antibodies deposit intraepidermally. On rare occasions,an additional “lupus band” of granular depositions of IgG and complement is seen along the epidermal basement membrane zone. This combined pattern has been connected with a ...

Desmoglein 3-Mediated Transinteraction Pemphigus Vulgaris IgG Directly Inhibit

The use of ELISA in pemphigus

Pemphigus is a group of autoimmune blistering diseases. There had been abundant evidence that antibodies against components within the desmosomes were responsible for its pathogenesis. The major antigens in pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 (130 kDa) and desmoglein 1 (160 kDa) respectively. They are glycoproteins belonging to the cadherin family and form part of the tr...

Pemphigus is an autoimmune intraepidermal blistering disease (1). The autoimmune target of the antibodies is desmoglein, a cadherin-like cell-to-cell adhesion molecule found in desmosomes. In pemphigus vulgaris

© 2014 The Authors. doi: 10.2340/00015555-1811 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Pemphigus is an autoimmune intraepidermal blistering disease (1). The autoimmune target of the antibodies is desmoglein, a cadherin-like cell-to-cell adhesion molecule found in desmosomes. In pemphigus vulgaris (PV), the main antigen is desmoglein 3 (Dsg 3), which is located on t...